FiTCHETT. — Physiological Action of Tutin. 361 



P.M. ^^- 1^^- 



3.14. Two drops of a 0"5-per-cent. solution of coriamyrtin introduced into the left eye 



of a cat. 



3.16. No change in size of pupil observed. 



3.22. No change. 



3.30. Pu])ils equal, and react to light with equal readiness. 



4.0. Pupils appear to be ec^ual. 



4.30. No change. 



Exp. 166. 



Rabbit. Weight, 777 grams. 



Jan. 24. At 4.50 gave 13-2 minims of a 0-1-per-cent. solution tutin (1 mlgm. per kilo), 



hypodermically. 

 „ 25. No obvious effect. 



,, 27. Gave 13-2 minims of a 0-1-per-cent. solution, per os. 

 ., 28. Normal, so gave 13'2 minims of a 0'1-per-cent. solution, per os. 

 ,, 30. Repeated dose of 13-2 minims of a 0'1-per-cent. solution, given jier os. 

 f'eb. 4. Weight, 848 grams. Gave 21-6 minims of a 0-1-per-cent. solution (1-5 mlgm. 



per kilo), per os. 

 ,, 8. Normal. Gave 4 minims of a 0-5-per-cent. solution tutin (1-5 mlgm. per kilo), 



per OS. 

 ,, 11. Weight, 879 grams. Gave 2 mlgm. per kilo, per os. 

 ,, 12. No symptoms ; normal. 

 ., 14. Weight, 862 grams. Gave 7-3 minims of a 0"5-per-cent. solution tutin (2-5 mlgm. 



per kilo), per os. 

 „ 17. Weight, 922 grams. Normal, so gave 7"8 minims of a 0-5-per-cent. solution 



tutin (2-5 mlgm. per kilo), per os. 

 „ 20. Normal. 

 „ 24. Weight, 958 grams. Normal, so gave 9 "7 minims of a 0-5-per-cent. solution 



(3 mlgm. per kilo), per os, 

 ,, 27. Weight, 983 grams. Gave 11-6 minims of a 0-5-per-cent. solution (3 mlgm. per 



kilo), par os. 

 Mar. 3. Weight. 991 grams. Gave 13-4 minims of a 0"5-per-cent. solution (4 mlgm. 



per kilo), per os. 

 ,, 7. Normal. Gave 5 mlgm. per kilo, per os. 

 ,, 9. Normal. 

 ,, 12. Weight, 1,154 grams. At 2.40 p.m. gave 23-5 minims of a 0"5-per-cent. solution 



tutui (6 mlgm. per kilo), per os. At 4 p.m. shows symptoms ; extends fore 



and hind limbs, and lies on belly ; ears and head tremulous. 

 ,, 16. Weight, 1,181 grams. Gave 7 mlgm. per kilo. Not continuously observed. 



Recovered. 

 ,. 19. Weight, 1,176 grams. Gave 8 mlgm. per kilo. In 3| hours showed symptoms 



(twitching of ears, chewing-movements, &c.). Recovered. 

 ,, 24. Gave 11-6 mlgm. per kilo, per os. Result, death in two hours. 



Exp. 167. 

 Jan. 24. Guinea-pig. Weight, 627 grams. 



P.M. 



5.0. Gave 10-2 minims of a 0'1-per-cent. solution of tutin (1 mlgm. per kilo), hypo- 

 dermically, with antiseptic })recautions. 

 6.30. Convulsive movements of jaw ; animal standing in unnatural attitude. 

 Jan. 25. Apparently normal. 

 ,. 27. Gave 10*2 minims of a 0-1-per-cent. solution tutin (1 mlgm. per kilo), per os. 

 ,. 28. Showed no symptoms ; normal to-day, so repeated dose, 10-2 minims per os. 

 ,, 30. No symptoms ; repeated dose, 10-2 minims, per os. 

 Feb. 4. Weight, 644 grams. At 5.36 p.m. mtended to give 17 minims of a 0-1-per-cent. 

 solution tutin (1-5 mlgm. per kilo), per os, but syringe not set before giving, 

 and so probably less than 17 minims given. 

 Feb. 8. 



P.M. 



5..50. Intended to give 17 minims of a 0-1-per-cent. solution tutin, per os, but 17 minims 

 of a 0-5-])er-cent. solution was given by mistake. Mistake discovered, and 

 0-5-per-cent. gram chloral-hydrate'given, per rectum, at 6.5 p.m. Immediately 

 on withdrawing nozzle of syringe a few pellets of f^ces were discharged, but 

 very little fluid returned. 



