362 Transactions. 



P.M. • 



6.20. Is under the influence of chloral, but showing twitches of fore limbs. 



7.5. Apparently still under chloral ; is quite limp. • \Y 



9.0. Awake, and easily startled ; ears cold, and whole body shivering ; was wrapped 



in towel. 

 9.20. Will not remain covered up. Shivering not so marked. 

 10.0. Same. 

 Feb. 9. 



A.M. 



9.0. Apparently normal, quite warm, breathing is regular. 



P.M. 



2.0. Does not seem to have eaten ; seems dazed. 

 II. 0. Did not try to escape when went to lift it, but resents being handled ; otherwise 



appears normal. 

 Feb. 10. 



A.M. 



9.0. Seems stiff in the hind quarters ; moans when touched ; has not eaten. Noticed 

 moist condition of uroanal opening. 



P.M. 



2.30. Completely paralysed, and cold in hinder half of body ; breathing thoracic ; 

 eyes kept wide open ; moans when liandled, and showed some convulsive 

 movements of fore limbs and head. 

 3.0. Found dead. 



P.M. — Stomach distended with gas ; intestines contain mixed gas and fluid contents ; 

 jieritoneum much injected ; appearance suggestive of general peritonitis. 



Exp. 168. 

 Feb, 27. Cat. Weight, 2-686 kilograms. 



P.M. 



5.12. Gave 13 minims of a 0-13-per-cent. solution of picrotoxin (0-375 mlgm. per kilo), 



hyjjodermically. 

 5.22. Quite normal ; cleaning itself. 

 5.30. , 

 5.35. 

 540' ' '^3'™^- ^o departure from the normal. 



6.30. ) 

 Feb. 28. Quite normal. 



Exp. 169. 

 Mar. 3. j; if. Same cat. Weight, 2-699 grams. Fresh solution of picrotoxin. 



P.M. 



4.0. Gave 6-8 minims of a 0-25-per-cent. solution picrotoxin, freshly prepared (0-375 



mlgm. per kilo), hypodermically. 

 4.16. No symptoms. 

 4.20. Has defaecated, and swallows occasionally, but seems so well that these may be 



normal appearances. 

 5.15. No apparent abnormality. 

 5.40. Same. 

 Mar. 4. Has displayed no symptoms, and seems jjerfectly well. 



Exp. 170. 

 Cat. Weight, 2-699 kilograms. 

 This cat previously received 1 mlgm. tutin, and recovered ; will now receive an 



equimolecular solution of picrotoxin, ||^ x 1 mlgm. picrotoxin = 2-66 mlgm. 



picrotoxin = 18 minims of a 0-25-per-cent. solution picrotoxin. 

 P.M. 



5.20. Gave 18 minims of a 0-25-per-cent. solution of jjicrotoxin. 

 6.0. No symptoms as yet, beyond occasional swallowing. 

 6.7. Salivating; mouth open, panting, vomited; vomiting repeated several times; 



breathing slower after vomiting ; defaecated 

 6.10. Retching; this a more marked symptom "than with tutin. Animal looks much 



less disturbed than with tutin at this stage. 

 6.15. Every now and then spasmodic contraction of diaphragm, suggesting hiccough; 



looks sleepy. 

 6.20. Twitching affecting fore paws only ; no face or ear twitching. 

 6.25. Twitching again, more marked, causing a little spring with fore ]iart of body; 



is very easily startled- y ■ '^ ^ j~ 



