\ 



FiTCHETT. — Physiological Action of Tntin. 365 



Exps. 176, 177, 178, 179. 



Four froths. Weights : A, 27 grams (Exp. 176) ; B, 37-5 grams (Exp. 177) ; 



C, 28 grams (Exp. 178) ; D, 34-5 grams (Exp. 17!>)- 



p. M. 



6.0. To each frog was given 0-012 gram chloral-hydrate, hypodermically. It was 

 intended to give 0-008 gram chloral-hydrate to frog.s C and D, but by mistake 

 they received the same dose (0-012 gram) as A and B. 



6.5. B received 15-3 minims of a O-OS-jier-cent. solution tutin (12m]gm. per kilo), 

 hypodermically ; C received 10-4 minims of a O-05-per-cent. solution tutin 

 (11 mlgra. per kilo), hypoderraic^iliy ; D received 14 minims of a 0-Oo-per-cent. 

 solution tutin (12 mlgm. per kilo), hypodermically. 



Next day. A is normal, B is dying, C is dead, D is dying. 



Exp. 180. 



yjj Rabbit. Weight, 1-4 kilograms. 



5 55. Gave 1-5 grams urethane, by stomach-tube. 



G.20. Apparently under, very sleepy and limp. Gave 4 mlgm. tutin per ld!o, hypo- 

 dermically. 



7.30. Symptoms first observed ; they were not present at 7.15 p.m. 



8.0. Twitching of ears and head, and starts of fore part of body ; no salivation ; was 

 handled a little roughly in trying to see if salivation present, and went into a 

 typical fit ; it lay on one side, and fit succeeded fit in rapid succession ; move- 

 ments chiefly clonic ; no tonic phase could be detected. 



8.30. As fits still continue, and animal seemed doomed, tried about 1 e.e. of a 10-per- 

 cent, sodium-carbonate, per rectum. While giving injection noticed involun- 

 tary urination. 



8.45. Sodium-carbonate had produced no obvious effect, so tried chloroform ; ad- 

 ministered it as carefully as possible, ^vith a Skinner's mask ; breathing was 

 shallow and rapid ; under influence of chloroform animal became cjuiet, move- 

 ments of limbs ceased, head moved slowly backwards, and breathing ceased 

 suddenly without the least warning ; the heart could not be felt beating, and 

 artificial respiration had no effect. 



Exp. 181. 



Feb. 4. Rabbit was chloroformed, stomach-tube passed ; 0-85 e.c. paraldehj^de (1-2 e.e. 



p.m. per kilo), dissolved in 10 c.c. water, given. 



5.0. Noticed that reflexes had returned. 



6.15. Asleep. 

 Feb. 5. Recovered. 



Exp. 182. 



p_jj_ Rabbit. Weight, 1-551 kilograms. 



4.48. Gave ^^ grain hypodermic tabloid of hyoscine hydrobrom, hypodermically. 



5.15. Apparently no effect, so gave a second dose of 5-J„ grain, per os. 



6.5. No effect. 



Next day. Normal. 



Eeferences to Literature 



1. " Life and Voyages of Captain James Cook." By Andrew Kippis, 



D.D., F.R.S. London : George NeAvnes (Limited) ; 190L P. 179. 



2. Lijttelton Times. Vol. i, No. 1, p. 6 ; 11th January, 1851. 



3. " On the Toot Plant and Poison of New Zealand." By W. Lauder 



Lindsay, M.D., F.R.S. Edin. British and Foreign Medico-Chirw- 

 gical Review, No. Ixxi ; Julv, 1865. 



4. " Story of New Zealand." By A. S. Thomson, M.D. 1859. 



5. Otago Colonist. 25th October, 1861. 



6. Otago Daily Times. 15th November, 1862. 



7. " Studies on the Chemistry of the New Zealand Flora." By T. F. 



Easterfield and B. C. Aston. Trans. N.Z. Inst., vol. xxxiii (1900). 



8. " Plants of New Zealand." By R. M. Laing, B.Sc, and E. W. Black- 



well. New Zealand, 1906. P. 228. 



