360 Transactions. 



Exp. 159. 



The experiment was repeated with a sixth frog. This was beheaded a Httle in front 

 of the anterior border of the tympanic membrane, so as to sever all in front of the top 

 of the medulla. 



Frog F 



Average .. .. ..8-5 9-1 



1 minim of a 0-5-per-cent. solution was then injected under the skin of the back, and 

 8 miniites later the test reapplied. 



Right Foot. Left Foot. 



Frog F . . . . . . . . 10" 10" 



-.38" 38" 



..84" 84" 



Average . . . . . . 44" 44" 



As a result of letting the frog fall on the table, a typical tutin sjjasm, with croaking, 

 occurred here. Seemed to require severe irritation to induce a spasm. A spasm occurred 

 on striking sharply with a glass rod. 



250 seconds were counted, but feet not withdrawn. Slight twitches occurred, 

 however, at 58", 71", 86", 94", and 120". 100 seconds more, but no effect. 



Although the acid had ceased to have any influence, it was still possible to elicit 

 reflex action on painful stimulation — e.g., pinching. 



Ten minutes later reflexes could not be elicited in any way. The thorax was then 

 opened, and the heart found to be still beating. The auricles were distended. Twitcliing 

 occurred as the cord was being pithed. 



Exp. 160. 



A few drops of a solution of tutin were introduced into the right eye of a young 

 rabbit. Within a few minutes there seemed to be a very slight dilatation. In an hour 

 and a c[uarter the right pupil was thought to be slightly the larger by an observer ignorant 

 of which eye had been subjected to the test, but the difference was so very slight, if 

 existing at all, that the result was regarded as doubtful. 



Exp. 161. 



Four small drops of a 0-5-per-cent. solution tutin were introduced into the left 

 conjunctival sac of a rabbit. It was observed for 15 minutes, and no change in the size 

 of the pujiil was noted. No hyper£emia of the conjunctiva resulted, nor did the con- 

 junctiva become less sensitive. 



This rabbit died twenty-four hours later, after exhibiting symi^toms of tutin 

 poisoning. 



Exp. 162. 



2.50. Two droits of a 0-5-per-cent. solution of tutin introduced into the right eye of a 



cat. 

 2. 52. No apparent effect. 

 2.55. No change. 

 3.0. No change. 



3.5. Pupils are the same size, and react equally to light. 

 3. 10. No effect. 

 4.0. Pupils equal. 



Exp. 164. . 



3.25. 0-5 c.c. of a 0-5-per-cent. solution of coriamyrtin was instilled into the right eye of 



a rabbit. 

 3.30. No ai>parent effect. 



3.35. Difficult to say if any effect ; the right eye may possibly be slightly contracted. 

 3.40. An observer ignorant of which eye had been treated was unable to distinguish 



any difference between the two pupils. 

 4,0. Pupils appear equal, and react to light with equal readiness. No appearance 



of irritation of conjunctiva. 



