was not determined. The change in specific gravity may represent an 

 alteration of red cell lipid content, cell water content, cell electrolyte 

 concentration, or a combination of the three. Most changes in red cell shape 

 induced by intrinsic factors and those related to aged red cells are not 

 readily reversible. This observation would support the concept of a change in 

 one of the plasma constituents and its uptake by the cell membrane as being 

 the primary cause of the shape changes. The significance of the observed red 

 cell shape transformation is not readily apparent. 



PUBLICATIONS : 313, 316, 317, 318 



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