PRINCIPAL INVESTIGATORS ): Carolyn S. Leach 



EXPERIMENT TITLE/NUMBER : Biochemistry and Endocrinology Results 



PROGRAM/MISSION : Apollo-Soyuz Test Project 



CLASSIFICATION : Human 



DISCIPLINE(S) : Endocrinology, Environmental health 



OBJECTIVES : To provide data which would permit an objective assessment of the 

 individual crewman's health. The data collected during pref light provided 

 baseline information for detecting and identifying postflight physiological 

 changes which may have resulted from exposure to the space flight environment. 



PROTOCOL : Analyses were performed on venous blood on days F-30, F-15, and 

 F-5. Postflight blood was drawn as soon as possible after recovery and R+28. 

 All pref light blood samples were obtained after fasting. On the same day that 

 blood was drawn, 24-hour urine samples were collected from each crewman. 



EQUIPMENT : Blood collection device, urine collection device. 



RESULTS : BUN, creatinine, and SGPT were elevated postflight. A decrease was 

 seen in CPK, uric acid, cholesterol, and triglycerides. A postflight decrease 

 in urine volume, Na , K, CI, and POj., and an increase in Ca excretion were 

 found. Cortisol, aldosterone, and angiotensin were elevated at R+0. ADH and 

 norepinephrine were decreased at R+0. All were decreased R+28. 



CONCLUSIONS : The test results of U. S. crewmen on the 9-day ASTP flight were 

 similar to the findings on recovery of previous space flight crews from 

 missions of comparable duration. 



PUBLICATIONS : 33 1 *, 339 



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