PRINCIPAL INVESTIGATOR (S ): W. Ross Adey, and P. M. Hahn 



EXPERIMENT TITLE/NUMBER : Biosatellite III Results 



PROGRAM/MISSION : Biosatellite III 



CLASSIFICATION : Animal - Pig-tailed monkey ( Macaca nemestrina ) 



DISCIPLINE(S) : Neurosensory, Behavioral science, Musculoskeletal, Urogenital, 

 Chronobiology 



OBJECTIVES : To create a small laboratory with a single environmental shift 

 which cannot be duplicated on earth (weightlessness) and observe the 

 physiological effects on a pig- tailed monkey. 



PROTOCOL : The animal was surgically implanted with deep-brain electrodes and 

 thermisters, two arterial and two venous vascular catheters and a suprapubic 

 urethral catheter in order to obtain neurophysiological , cardiovascular, and 

 renal function data. Subcutaneous electrodes were used to obtain ECG and ZPN 

 data. The animal was also trained to perform a series of psychomoter 

 performance tasks during the flight. Additional pref light and postf light 

 studies included assessments of body composition, skeletal mineral and 

 hematological effects of long-duration space flight. 



EQUIPMENT : Bipolar electroencephalograph electrodes, electrooculographic 

 sensors, electromyographic leads, heart function and respiration sensors, 

 vascular catheters, temperature sensors in brain and peritoneal cavity, 

 urinary catheter, transducers, life support system, visuomotor and delayed 

 matching task equipment. 



RESULTS : The mission was terminated on the ninth mission day after 

 telemetered data indicated significant physical deterioration of the animal. 

 The animal died approximately 8 hours after recovery. The acute cause of 

 death was ventricular fibrillation. Data telemetered during the flight 

 indicated significant (2-3 cm H20) elevations in central venous pressure 

 coupled with normal arterial pressures and heart rates. EEG data showed a 

 progressive deterioration in cortical function through the latter half of the 

 flight. Temperature, heart rate and respiration data showed a desyncronosis 

 with periods of greater than 24 hours. Blood pressure rhythms were not larger 

 than 24 hours. Autopsy (10 hours after death) showed a bruised spot on the 

 heart, petechial hemorrhages in the ileum, congestion and edema of the lungs, 

 and thrombi in the circulatory system. 



CONCLUSIONS : It was surmised that the deterioration in the physical condition 

 of the animal prior to recovery was due to dehydration and an associated 

 electrolyte imbalance. 



PUBLICATIONS : 2, 4, 7, 369 



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