PRINCIPAL INVESTIGATOR(S ) : D. 0. Walter, J. I. Berkhout, R. Buchness, E. 



Kram, L. Rovner, and W. Ross Adey 



EXPERIMENT TITLE/NUMBER : Digital Computer Analysis of Neurophysiological Data 



from Biosatelllite III 



PROGRAM/ MISSION : Biosatellite III 



CLASSIFICATION : Animal - Pig-tailed monkey ( Macaca nemestrina ) 



DISCIPLINE(S) : Neurosensory 



OBJECTIVES : To perform a short-term analysis to assist in animal monitoring 

 and mission abort decisions, and a long-term analysis to support general 

 physiological studies, including circadian studies. 



PROTOCOL : Data for the short-term analysis were available from telemetry 

 captures at prime stations: Quito, Ecuador; Lima, Peru; Santiago, Chile and 

 Fort Myers, Florida. Long-term data were available from the prime stations 

 and postf light analyses. 



EQUIPMENT : EEG, Digital magnetic tapes. 



RESULTS : The launch was a mildly traumatic event for "Bonny." The animal was 

 aroused throughout the task presentations on Days 2, 3, 4, and 5, even though 

 the level of performance was quite low. There were strongly circadian 

 fluctuations of brain temperature which may be related to intensity peaks of 

 the EEG. Flight induced pathology was first noted in cortical spectra early 

 in Day 7. During Day 8 and the first half of Day 9 the cortical spectra were 

 stable, although abnormally low in power. On Day 9, the mission was 

 terminated when there was a further decline in parietal intensity. Death 

 occurred R+8 hrs , the acute cause being ventricular fibrillation. 



CONCLUSIONS : The animal appears to have had a functionally intact cortex 

 until Day 6, and to have had a functional cortical impairment on Days 7 and 8, 

 which was compatible with a minimal response to alterations of light versus 

 dark and with a maintenance of normal subcortical electrical activity. The 

 animal became grossly pathological and unresponsive on Day 9. Considerable 

 fluctuations in spectral intensity persisted within certain frequency bands. 

 This pathological state resembled, but was not identical with, a state of 

 acute hypothermia under anesthesia. 



PUBLICATIONS : 2, 3, 4, 7, 557 



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