NOAEL -- 12.3 mg/kg/day 



UF -- 100 (allows for interspecies and mtrahuman variability) 



Assumptions -- 1 L/day water consumption for a 10-kg child 



Principal Study - MuUer et aJ., 1981 



Rats were fed lindane at daily doses of 1.3, 12.3, or 25.4 mg/kg bw in 



the diet for 30 days. Nerve conduction delay was observed in the 



animals fed a daily dose of 25.4 mg/kg but was not observed at dose 



levels of 12.3 or 1.3 mg/kg. A NOAEL of 12.3 mg/kg/day was identified. 



IIIAJ. LONGER-TERM HEALTH ADVISORY FOR A CHILD 



Longer-term (Child) HA -- 3.3E-2 mg/L 

 NOAEL -- 0.33 mg/kg/day 



UF -- 100 (allows for interspecies and intrahuman variability with the 

 use of a NOAEL from an animal study) 

 Assumptions -- 1 L/day water consumption for a 10-kg child 

 Principal Study -- Zoecon Corporation, 1983 



Male and female rats were fed lindane at dietary levels of 0, 0.2, 0.8, 4, 

 20, or 100 ppm for 84 consecutive days. Liver hypertrophy, kidney 

 tubular degeneration, hyaline droplets, tubular casts, tubular disten- 

 sion, interstitial nephritis, and basophilic tubules were observed in the 

 20 and 100 ppm groups. Effects were rare and very mild when noted 

 at 4 ppm. The NOAEL was considered to be 4 ppm in this study. 

 Based upon measured food consumption, the daily intake of hndane 

 at 4 ppm in the diet was 0.29 mg/kg in males and 0.33 mg/kg in females. 

 The dose of 0.33 mg/kg is identified as the NOAEL. 



1II.A.4. LONGER-TERM HEALTH ADVISORY FOR AN ADULT 



Longer-term (Adult) HA -- 1.2E-1 mg/L 



NOAEL - 0.33 mg/kg/day 



UF — 100 (allows for interspecies and intrahuman variability with the 



use of a NOAEL from an animal study) Assumptions — 2 L/day water 



consumption for a 70-kg adult 



Principal Study — Zoecon Corporation, 1983 (study described in 



III.A.3.) 



III.A.5. DRINKING WATER EQUIVALENT LEVEL / LIFETIME 

 HEALTH ADVISORY 



DWEL - lE-2 mg/L 



Assumptions — 2 L/day water consumption for a 70-kg adult 

 RfD Verification Date - 01/22/86 (see Section LA. of this file) 

 Lifetime HA - 2E-4 mg/L 

 Assumptions -- 20% exposure by drinking water 

 Principal Study - Zoecon Corporation, 1983 (This study was used in 

 the derivation of the chronic oral RfD; see Section I.A.2.) NOTE: A 

 safety factor of 10 was used in the derivation of this HA, in addition to 

 the UF of 1000 for the RfD, to account for the possible carcinogenicity 

 of this substance. The assessment for the potential human car- 

 cinogenicity of lindane is currently under review. 



HIA.6. ORGANOLEPTIC PROPERTIES 



No data available 



HI.A.7. ANALYTICAL METHODS FOR DETECTION IN DRINK- 

 ING WATER 



Determination of lindane is by a liquid-hquid extraction gas chromato- 

 graphic procedure. 



