Pathological Iron ^Ietabolism 95 



iron, and it is not possible that the iron will be closely linked with the 

 calcium and the phosphate metabolism. 



Aterman: If I remember your figures rightly there was in your "alti- 

 tude" animals a fairly high excretion of iron in the urine, higher than 

 in any of the other conditions. How would you explain that? 



Vannotti: I think it is related to a general stimulation of cell meta- 

 bolism from the hypoxia, and to an increase of the blood circulation in 

 the different organs, but I have not yet a clear explanation of this 

 phenomenon. We have also seen that there is a little higher fixation in 

 muscle in these cases. 



Aterman: Did you find anj^ variations in the amount of urine excreted 

 under these conditions? There is experimental evidence that anoxia 

 can produce anuria. 



Vannotti: That is a good hypothesis to follow, but I have unfortu- 

 nately not examined the excretion of urine in these cases. For me it was 

 more important to see the action of a severe hypoxia on erythropoiesis 

 and on cellular iron. 



