46 



H. O. HALVORSON 



TABLE III 



EFFECT OF SOME ORGANIC ACIDS ON THE INHIBITION OF SPORULATION BY 

 a-PICOLINIC ACID (1.2 X 10-3 ^^ 



Compound added to a-picolinic acid 



Concentration 

 mgjml 



Spondation 



Formic 



Malonic 



Propionic 



Methyl malonic 



Pimelic 



a-Ketopimelic 



Oxalic 



Adipic 



Glutamic 



Mesotartaric 



Lactic 



Pipecolic 



a-Aminopimelic 



a-Hydroxyglutaric 



DL-a-Methyl glutamic 



Glycolic 



^-Hydroxybutyric 



a-Ketoglutaric 



Fumaric 



Glyoxylic 



Pyruvic 



Acetic 



Citric 



m-Aconitic 



Isocitric 



Succinic 



Malic 



Oxalacetic 



2 



2 



2 



2 



2 



2 



2 



2 



2 



4 



1 



2 



2 



4 



1 



1 



1 



1.5 



1.5 



1.5 



0.5 



1 



1 



+ 



+ 

 + 

 + 

 + 

 + 



+ 

 + 

 + 

 + 

 + 

 + 

 + 



mediates in the tricarboxylic acid cycle and the glyoxalic acid 

 shunt reverse this inhibition except fumaric acid, ketoglutaric, 

 and glyoxalic acid. In addition, the inhibition is reversed with 

 a number of other acids. Most of these can readily enter the 

 cycles mentioned. Succinic acid proved to be the best reversing 



