THE BACTERIAL ENDOSPORE 59 



synthesis of dipicolinic acid. The only function the dipicoHnic 

 acid plays in the process is to produce a structure that can 

 protect the enzymes and make the spore heat resistant. Heat 

 resistance cannot develop until after the DPA has been synthe- 

 sized. This lends further circumstantial evidence to the theory 

 that dipicolinic acid is involved in the formation of a complex 

 which serves to protect the enzymes and makes them heat 

 resistant. 



ACKNOWLEDGEMENTS 



The unpublished results reported herein should not be 

 credited to any one individual but to a research team in which 

 the following have been my coworkers: Dr. Krishnamurty 

 Gollakota*, Research Associate and Assistant Professor of 

 Research; Dr. Robert Collier** and Dr. Herbert Nakata***, 

 former graduate students who have completed research for 

 their theses on some phase of this problem; Mr. Ivan Goldberg 

 and Mr. John DePinto, current graduate students; and Mr. 

 Francis Engle. laboratory assistant, and Leena Narasimhan, 

 research assistant. The above individuals are to be considered 

 as co-authors. 



This investigation was supported by grants from the Office 

 of Naval Research and the National Institute of Health. 



REFERENCES 



1 G. M. Hills, Biochem. 7., 45 (1949) 353. 



2 N. L. Lawrence and H. O. Halvorson, /. BacterioL, 68 (1954) 334. 



3 B. T. Stewart and H. O. Halvorson, /. BacterioL, 65 (1953) 160. 



^ B. T. Stewart and H. O. Halvorson, Arch. Biochem. Biophys., 49 



(1954) 168. 

 5 J. F. Powell, Biochem. J., 54 (1953) 210. 



* Present address: Director, School of Basic Sciences and Humanities, 



U.P. Agriculture University, Poolbagh (Dist. Nainital), India. 



** Present address: University of Oklahoma, Norman, Oklahoma. 



*** Present address: Department of Bacteriology & Public Health, State 



College of Washington. Pullman. Washington. 



