156 SUBCELLULAR PARTICLES 



secondly, because such a relationship, if it exists, cannot alter the fact that lyso- 

 somes are different from mitochondria, as defined on the basis of functional 

 and biochemical criteria. 



In the third part of this paper, an attempt has been made to link lysosomes 

 with the three natural processes of digestion, autolysis and necrosis, which could 

 be accomplished by their particular enzymic equipment. A few suggestive data 

 have been presented, but their number is still perilously small and great caution 

 is required in their interpretation. One of the weaknesses of the hypotheses 

 which have been examined is that no mention has been made of the neutral and 

 alkaline hydrolases, which are present in other parts of the cell. Obviously, the 

 part played by these enzymes in digestive and related processes, as well as the 

 manner in which their activities are held in check and controlled within the 

 cell, are matters of great interest about which, however, we know even less 

 than we do concerning the lysosomes. 



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