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77. Reid, E. and B. M. Stevens. Biochem. f. 67: 262, 1957. 



78. Reid, E. and B. M. Stevens. Biochem. }. 68: 367, 1958. 



79. Rhodin, J. (Monogr.) Stockholm: Aktiebolaget Godvil, 1954. 



80. Richter, G. W. /. Biophys. Biochem. Cytol. 4: 55, 1958. 



81. Rose, G. G. /. Biophys. Biochem. Cytol. 3: 697, 1957. 



82. RouiLLER, C. Compt. rend. soc. biol. Paris 148: 2008, 1954. 



83. RouiLLER, C. and W. Bernhard. /. Biophys. Biochem. Cytol. 2: Suppl. 355, 1956. 



84. Roy, A. B. Biochim. et biophys. acta 14: 149, 1954. 



85. Roy, A. B. Biochcm. /. 68: 519, 1958. 



86. Schneider, W. C. and G. H. Hogeboom. /. Nat. Cancer Inst. 10: 969, 1950. 



87. ScHULZ, H. E.\per. Cell Res. 11: 651, 1956. 



88. Simpson, M. V. /. Biol. Chem. 201: 143, 1953. 



89. SjosTRAND, F. S. and J. RiioDiN. Expcr. Cell Res. 4: 426, 1953. 



90. Steinberg, D. and M. Vaughan. Biochim. et biophys. acta 19: 584, 1956. 



91. Stevens, B. M. and E. Reid. Biochem. J. 64: 735, 1956. 



92. Straus, W. /. Biol. Chem. 207: 745, 1954. 



93. Straus, W. /. Biophys. Biochem. Cytol. 2: 513, 1956. 



94. Straus, W. /. Biophys. Biochem. Cytol. 3: 933, 1957. 



95. Straus, "W. /. Biophys. Bochem. Cytol. 3: 1037, 1957. 



96. Straus, W. and J. Oliver. /. Exper. Med. 102: i, 1955. 



97. Thomson, J. P. and F. }. Klipeel. Arch. Biochcm. Biophys. 70: 224, 1957. 



98. Thomson, J. F. and E. T. Mikuta. Arch. Biochem. Biophys. 51: 487, 1954. 



99. Thomson, J. F. and E. M. Moss. Arch. Biochem. Biophys. 61: 456, 1956. 



100. UNDERHAy, E., S. J. Holt, H. Beaufay and C. de Duve. /. Biophys. Biochem. Cytol. 2: 



635, 1956. 



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102. 'Wattiaux, R., p. Baudhuin, A. M. Berleur and C. de Duve. Biochem. /. 63: 608, 1956. 



103. 'Wattiaux, R. and C. de Duve. Biochem. /. 63: 606, 1956. 



104. Weber, R. Expcncntia 13: 153, 1957. 



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DISCUSSION 



V. It. Potter, C. de Duve, M. L. Weiss, D. A. Marsland 



Dr. Potter: What are the possible signals that set off the activation of the lysosomes 

 in the cells; for example, is lactic acid production a factor.' 



Dr. deDuve: One important factor is undoubtedly anoxia. See manuscript for pos- 

 sible mechanisms of anoxic rupture of lysosomes. 



Dr. 'Weiss: Coming back to the teleological point of view, would it not be possible 

 that the lysosomal enzymes which might be released upon cell death digest cell 

 constituents, making precursors available for regenerating cells; since where there is 

 destruction there is also regeneration? 



