VITAMIN AND GROWTH FACTOR RESEARCH 

 TABLE I (Continued) 



E. Biocytin 



1. Bioassay organisms used in detection: 



Lactobacillus arabinosus and Lactobacillus casei: Wright and 

 Skeggs, 1944 (85) 



2. Isolation 



Wright, Cresson, Skeggs, Wood, Peck, Wolf, and Folkers, 1 952 

 (86) 



3. Characterization and synthesis 



Wolf, Valiant, Peck, and Folkers, 1952 (40) 



F. Vitamin B12 



1 . Bioassay organisms used in detection : 

 Man: Castle, 1929 (10) 



Lactobacillus lactis Dorner: Shorb, 1947 (59) 



2. Isolation 



Rickes, Brink, Koniusy, Wood, and Folkers, 1948 (53); Smith, 

 1948 (60) 



II. Microbial growth factors of undetermined nutritional significance for 

 animals 



A. Lipoic acid (thioctic acid) 



1. Bioassay organisms used in detection 



Lactobacillus casei: Guirard, Snell, and Williams, 1946 (17) 



Streptococcus faecalis (enzymatic): O'Kane and Gunsalus, 1947 



(38) 



Tetrahymena geleii: Stokstad, Hoffman, Regan, Fordham, and 



Jukes, 1949 (78) 



2. Isolation 



Reed, DeBusk, Gunsalus, and Hornberger, 1951 (52) 

 Patterson, Brockman, Day, Pierce, Macchi, Hoflfman, Fong, 

 Stokstad, and Jukes, 1951 (46) 



3. Characterization and synthesis 



Hornberger, Heitmiller, Gunsalus, Schnakenberg, and Reed, 



1952 (25) 



Bullock, Brockman, Patterson, Pierce, and Stokstad, 1952 (9) 



HI. Bacterial growth factors of dubious significance for animal nutrition 

 Growth factor Test organism Investigators 



A. D-Alanine Lactic acid bacteria Snell, 1945 (63) 



B. Putrescine Hemophilus parainjiuenzae Herbst and Snell, 1948 



m 



Table continued 



91 



