GREGORY PINCUS 



been attempts to do so {cf. Russell and Wilhelmi (13)). Thus 

 the therapeutic effects of Cortisol do not correlate with its meta- 

 bolic effects; indeed several of the latter have been called 



GH3COOH 



HO 



HO 



A^-Pregnenolone 



11-Deoxycortisol 



(e) 



Progesterone 1 7-OH-Progesterone 



Fig. 1. A representation of the biosynthesis of Cortisol. 



"side effects." Though the antiphlogistic (or "anti-inflamma- 

 tory") effects appear to be primary to therapeutic effects, the 

 ameliorations observed in a wide variety of diseases lead one to 



182 



