RIBONUCLEIC ACIDS 



is at variance with or consistent with the template and protein- 

 synthesizing hypotheses (6,37,66) must await further clarification 

 of the biological role of undegraded RNA (6) . 



Thus the casual observation of isomerism in the adenylic 

 acids derived from RNA, a consequence of the introduction of 

 ion-exchange chromatography to the problems of nucleic acid 

 chemistry, has had far-reaching repercussions with respect to 

 nucleic acid structure, nucleic acid synthesis, nucleotide co- 

 enzymes, and the concept of a dyamic metabolic relationship 

 among these classes of compounds. 



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471 



