HAROLD P. RUSCH 



Theory of Cancer Formation 



Some aspects of carcinogenesis will now be considered. 

 Two of the conclusions concerning the nature of cancer made by 

 the committee in 1938 were that the causes of cancer "are mul- 

 tiple and diverse" and that "once malignancy is established in a 

 cell it becomes an automatic process. . .which is passed un- 

 changed to the descendants." Research during the intervening 



D-MECHANISM FOR CELLULAR REDUPLICATION 



O-MECHANISM FOR SPECIAL FUNCTIONS 



g;:,-C ELL- FOOD 



Figure 3. 



years has sustained this report, and, in addition, sufficient infor- 

 mation has been accumulated to indicate that all carcinogens 

 induce heritable cellular changes. 



This change is depicted in the alteration of the normal 

 cells B, C, and D to the neoplastic cells U, V, and W as shown 

 in Figure 3. At first glance little difference is noted between the 

 top two rows as to the patterns in the various cells; both have 

 the same quantity of cell food, and both possess considerable 

 specialized function. But one crucial difference exists. A key 

 reaction in one of the special metabolic patterns has been 



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