T L. Althausen 23 



amounts of estrone to aduli males and to adrenalectomized i ais does not in- 

 fluence their absorption of dextrose. Administration of estrone to young male 

 rats over a long period of time increases their intestinal absorption of dextrose 

 to the level of female rats. These data indicate that tlic male sex hormone has 

 no influence on intestinal absorption, whereas the female sex hormone in an 

 indirect way has a stimulating elfect on the absorption of substances suscep- 

 tible to phosphorylation. 



4. Hypophysectomy significantly lowers the rate of absorption for dextrose 

 in rats. Administration of an active extract of the anterior pituitary to normal 

 rats fails to alter intestinal absorption. vSince very small amounts of thyroxin 

 restore the absorption of dextrose in hypophysectomized rats to normal, it is 

 possible that the absence of the hypophysis exerts its effect on absorption in- 

 directly through lack of the thyrotrophic hormone. 



Conclusions 



The thyroid hormone exerts a direct stimulating influence on intestinal ab- 

 sorption of substances susceptible to phosphorylation. The female sex hormone 

 and the hypophysis have a similar but indirect influence. The adrenals and the 

 testes do not affect intestinal absorption except when lack of adrenal cortical 

 hormone produces impairment of general health or of sodium metabolism. 



REFERENCES 



1. Althausen, T. L., and Stockholm, M.: Amer. Jl. Physiol. 123:577, 1937. 



2. Verzar, F., and McDougall, E. J.: Absorption from the Intestine (London. New '^'ork. and 



Toronto: 1936). 



3. Eiler, J. J.; Stockholm, M., and Althausen, T. L.: jl. Biol. Chem. 131:283, 1940. 



4. Lundsgaard, E.: Skandinav. Arch. f. Physiol. 72:265, 1935. 



5. Walker, A. M., and Hudson, C. L.: Amer. Jl. Phvsiol. 118:130, 1937. 



6. Shannon, J. A., and Fisher, S.: Amer. Jl. Physiol. 122:765, 1938. 



7. Eiler, J. J.; Althausen, T. L., and Stockholm, M.: In preparation. 

 S. Kalckar, H.: Biochem. Jl. 33:631, 1939. 



9. Colowick, S. P.; Welch, M. S., and Cori, C. F.: Jl. Biol. Chem. 133:359- '940. 



10. Althausen, T. L.; Lockhart, J. C, and Soley, M. H.: Amer. Jl. Med. Scis. 199:342, 1940- 



11. Althausen, T. L.: Jl. Amer. Med. Assn. 115:101, 1940. 



12. Wilbrandt, W., and Lengyel, L.: Biochem. Ztschr. 267:201. 1933. 



13. V. Issckutz, B., jun.; Laszt, L., and Verzar, F.: Pfliigers Arch. f. d. gs,„t. Phvsiol. 240:612. 



1938. 



14. Deuel, H. J., Jr.; Hallman. L. F.; Murray, S., and Samuels. L. T.: Jl. Biol. Ciiem. 1 19:607. 



1937. 



15. Althausen, T. L.; Anderson, E. M., and Stockholm. M.: Proc. Soc. Exper. Biol. .^- Med. 40: 



342, 1939- 



16. Marrazzi, R.: Amer. |1. Physiol. 131:36. 19 1«- 



17. Anderson, E. IsL; Herring, V., and Joseph, M.: Proc. Soc. Exper. Biol. & Med. 45:488, 1940. 



18. Long, C. N. H.; Katzin, B., and Frey, E. A.: Endocrinology 26:309, 1940. 



19. Alth!ausen, T. L.; Stockholm, M., and Anderson, E.: Amer. Jl. Physiol. 126: i^;.). 1939. 



20. Russell, J. A.: Amer. Jl. Physiol. 121:755. 1938- 



21. Russell, J. A.: Proc. Soc. Exper. Biol. & Med. 37:569. 193^ 



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