S. C. Freed igg 



Conclusions 



Two synthetic estrogens, diethylstilbestrol and hexestrol, have been tested for 

 their therapeutic efficiency by assay in humans. The subjective response of 

 menopausal patients Avas used as the end point in this assay and the usual 

 uncontrolled factors encountered in such a study were eliminated to a great 

 extent by using multiple dosage levels of estrogens, as well as other precau- 

 tions. From the results obtained, it can be concluded that hexestrol is about 

 one-fifth as effective as diethylstilbestrol in the human. It is indicated that 

 hexestrol is significantly less liable to induce undesirable reactions than di- 

 ethylstilbestrol at equivalent therapeutic dosages. 



REFERENCES 



1. Freed, S. C: Jl. Amer. Med. Assn. 117:1175, 1941. 



2. Papanicolaou, G. N., and Shorr, E.: Amer. Jl. Obstet. & Gynecol. 31:806, 1936. 



3. Werner, A. A.: Internatn. Abstr. Surg. 73:49, in Surg. Gynecol. & Obstet., 1941. 



4. Novak, E., and Richardson, E. H.: Amer. Jl. Obstet. & Gynecol. 42:564, 1941. 



5. Bishop, P. M. F.; Bowes, R. K.; Boycott, M.; Kellar, R.; MacGregor, T. M., and Murless, 



B. C.: Lancet 238:629, 1940. 



