2 1 2 Functional Interrelations o£ the Brain Stem 



logical standpoint, an area 4-ablation is likely to be more effective than an 

 ablation of area 6; but if, as Klemme maintains, a large ablation of area 6 gives 

 symptomatic arrest for an indefinite period it would clearly be the operation 

 of choice, since area 6-lesions are accompanied by far less ultimate motor 

 deficit than in the case of lesions of area 4. 



This field of work is still in its experimental stages and I believe that the 

 solution can come only through further clinical experience. I am confident, 

 furthermore, that in severe cases the operation is entirely justifiable and I 

 sincerely hope that physiologically minded surgeons and neurologists will 

 continue to encourage studies of this character, for they may bring relief in 

 conditions which in years past have been regarded as entirely hopeless. 



REFERENCES 



1. Levin, P. M.: J. comp. Neurol. 63:369, 1936. 



2. Mettler, F. A.: J. comp. Neurol. 61:221, 509; 62:263; 63:25, 1935. 



3. Verhaart, W. J. C, and Kennard, M. A.: J. Anat. 74:239, 1940. 



4. Ramon y Cajal, S.: Histologic dii Systeme Nerveux de I'Homme et des Vertebres (Paris: 



1909-1911). 



5. Dusser de Barenne, J. G., and McCulloch, W. S.: J. Neurophysiol. 2:319, 1939. 



6. Hines, M.: Amer. J. Physiol. 116:76, 1936. 



7. Hines, M.: Johns Hopk. Hosp. Bull. 60:313, 1937. 



8. Dusser de Barenne, J. G.: Garol, H. W., and McCulloch, W. S.: Res. Publ. Ass. nerv. ment. 



Dis. (1940) 21:246, 1942. 



9. Rioch, D. M., and Brenner, C: J. comp. Neurol. 68:491, 1938. 



10. Fulton, J. F.: Trans. Coll. Phys. Philad. 8:157, 1940. 



1 1. Mettler, F. A.; Ades, H. W.; Lipman, E., and Culler, E. A.: Arch. Neurol. Psychiat. 41:984, 



1939- 



12. Tower, S. S.: Brain 63:36, 1940. 



13. Kennard, M. A.: Arch. Neurol. Psychiat. 48:227, 1942. 



14. Hines, M., and Boynton, E. P.: Contr. Embryol. Carn. Instn. 28:309, 1940. 



15. Kennard, M. A., and Fulton, J. F.: Res. Publ. Ass. nerv. ment. Dis. (1940) 21:228, 1942. 



16. Dow, R. S.: Arch. Neurol. Psychiat. 40:500, 193S. 



17. Dow, R. S.: J. comp. Neurol. 68:297, 1938- 



18. Miller, F. R., and Banting, F. G.: Brain 45: 104, 1922. 



19. Connor, G. J., and German, W. J.: Trans. Amer. Neurol. Ass. 1941:181. 



20. Fulton, J. F.; Liddell, E. G. T., and Rioch, D. M.: Arch. Neurol. Psychiat. 28:542, 1932. 



21. Bucy, P. C, and Buchanan, D. N.: Brain 55:479, 1932. 



22. Bucy, P. C: Res. Publ. Ass. nerv. ment. Dis. (1940) 21:551, 1942. 



23. Putnam, T. J.: Res. Publ. Ass. nerv. ment. Dis. (1940) 21:666, 1942. 



24. Meyers, P.: Res. Publ. Ass. nerv. ment. Dis. (1940) 21:602, 1942. 



25. Klemme, R. M.: Res. Publ. Ass. nerv. ment. Dis. (1940) 21:596, 1942. 



26. Aring. C. D., and Fulton, J. F.: Arch. Neurol. Psychiat. 35:439, 1936. 



