Irvine McQiiarrie 425 



been shown to be antagonistic to each other in the main. Sodium tends to re- 

 tard the oxidation of glucose and to increase the deposition of glycogen in the 

 liver. On the other hand, potassium inhibits glycogenesis in the liver and 

 tends to increase blood sugar and glycosuria at the expense of liver glycogen. 

 Under certain conditions it apparently activates the enzymatic breakdown 

 of glucose. 



The clinical significance of these interrelationships is apparent in such con- 

 ditions as diabetes mellitus, hyperinsulinism, Addison's disease and familial 



periodic paralysis. 



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