van Wagenen and Hamilton 589 



The gonads were ovaries and contained no testicular tissues. The uterus re- 

 sembled that of the control animal (compare pi. 5, fig. 21, and pi. 3, fig. 13). 



The vagina (pi. 5, figs. 22 and 23) was imperfectly formed. It consisted of two 

 distinct dorsoventrally flattened tubes that from respective openings in the 

 cervix and vestibule approached one another to overlap and end blindly. The 

 overlapping extended for 1.6 mm. at the level of the neck of the bladder and 

 in this region the two vaginal canals intercommunicated (pi. 5, fig. 23). Each 

 part of the vagina possessed a separate muscular coat except in this region. The 

 portion of the vagina opening to the exterior was the more ventrally placed, 

 lying between the uterine portion of the vagina and the urethra. The two 

 parts considered as a single vaginal canal resembled the vagina of the control 

 animal in that a lumen was present only in the inner and outer thirds of its 

 length. The lumen was lined with pseudostratified columnar epithelium for 

 the most part, but the type of epithelium was variable with occasional patches 

 of cuboidal cells. The nuclei were oval in shape and in the taller cells tended 

 to lie in the middle third. 



Seminal vesicles and prostatic tissue were not observed. The bulbo-urethral 

 glands lay ventral to the urethra as in the male, thereby differing from the 

 position of the glands ventral to the vagina in the normal female. 



Tissues surrounding the vestibule had cavernous spaces, which in the parts 

 lateral and ventral to the vestibule were especially noticeable (pi. 5, fig. 24). 

 The clitoris, including cavernous tissues, was well developed. The homologue 

 of the OS penis was present in the form of an elongated column of fibrous tissue 

 (pi. 5, fig. 25). 



There was a distinct modification of the skin and underlying tissues com- 

 posing the sex swellings. The epidermis was thin, with the stratum inter- 

 medium lacking or reduced to a single layer. In this region the subepidermal 

 tissue formed bilateral mounds of loosely arranged tissue of the same char- 

 acter as that in the scrotum of the normal male fetus. The transition between 

 the compact tissue of the corium of the normal skin and the scattered cells 

 of the scrotal swellings was definite but not abrupt. 



Fetus 6y, Female Complete Pseudohermaphrodite. The mother of this 

 genetic female received daily injections of 20 mg. of testosterone propionate 

 from the forty-first to the ninety-ninth day of pregnancy. Structures, apparently 

 a scrotum and penis, were developed at the location where normally these 

 organs are found in males and quite removed from the usual position of the 

 clitoris in females (pi. 1, fig. 5). The scrotum, like that of the control male, was 

 large and bilobed with the phallus lying partially embedded between the lobes. 

 There was no vestibular orifice in the perineimi but there was instead a 

 prominent raphe in the midline extending from the anus to the urethral 

 meatus. The phallus was hypospadiac, no gonadal mass was palpable in the 

 scrotum or inguen. 



Internally the uterus and adnexa were similar to those shown in plate 7, fig- 



