van Wagenen and Hamilton 593 



Summary 



Genetic female monkey fetuses, the mothers of which had been treated with 

 androgenic hormone, developed as pseudohermaphrodites and exhibited 

 anomalies which closely resemble those observed in human female pseudo- 

 hermaphroditism (table 2). 



Six pregnant monkeys received daily injections of 5 to 20 mg. of testosterone 

 propionate beginning upon the forty-first to fifty-ninth days of gestation and 

 ending about the one hundredth day. Fetuses were removed from these ani- 

 mals at the end of the period of treatment. Two males and one female fetus, 

 removed from untreated mothers at a similar time in gestation, were studied 

 as control specimens. 



The series of fetuses from mothers which had received hormone included 

 three genetic females, two of which were pseudohermaphrodites and one 

 which was less extensively modified by the treatment. One fetus was a genetic 

 male which showed relatively little stimulation. 



The female pseudohermaphrodites had external genitalia that were male 

 in appearance with a penis-like phallus containing the urethra lying cephalad 

 to a well-formed scrotum. Internally, the tuerus, uterine tubes, and upper 

 portion of the vagina were normal in structure and position. The vagina 

 ended in the dorsal wall of the prostatic urethra and bore a striking re- 

 semblance to a prostatic utricle. Prostatic glands were present and as large 

 as those of the control male; they surrounded the vagina and had developed 

 as outgrowths of the urogenital sinus, both above and below the Miillerian 



tubercle. 



Conclusion 



An exogenous androgen can pass through the placenta to induce pseudo- 

 hermaphroditism in the female young of the monkey. 



Grateful acknowledgment is made to Miss Natalie MacCarthy, IVIr. Frank 

 Caruso, and Mr. Joseph Negri who assist in the research of the Department 

 of Obstetrics and Gynecology. 



Testosterone propionate was furnished under the trade name Perandren 

 by Ciba Pharmaceutical Products, Inc., and Oreton by the Shering Corpora- 

 tion. 



REFERENCES 



1. DantchakofT, \'.: Cpts. id. Soc. de biol. 123:873, 1936. 



2. Greene. R. R., and Ivy, A. C: Science (n.s.) 86:200, 1937. 



3. Johnson, F. P.: Jl. Urol. 8:13, 1922. 



4. Young, H. H.: Genital Abnormalities, Hermaphroditism and Related Adrenal Diseases 



(Baltimore: 1937). 



5. Hamilton, f. B., and Gardner, W . I'.: Proc. Soc. Exper. Biol, c^- Med. 37:370, 1937. 



