ADJUSTMENT TO INFECTIOUS DISEASE 427 



some time before the administration of virulent organisms 

 may be shown to react with an energetic formation of 

 inflammatory granulation tissue which protects them 

 in a manner fundamentally different from that involved 

 in the antigen-antibody mechanism which we have described. 

 Too httle is known about the nature of these reactions to 

 make it possible to discuss them inteUigently, but it must 

 not be forgotten that they exist and that while they are 

 much more difficult to investigate, gradual progress is 

 being made in their comprehension. 



It is hardly necessary to state that no adequate presenta- 

 tion of the problems of immunology can be made in the 

 brief space available. The study of the adjustment of the 

 human body to infection is in that transitional stage in 

 which a great volume of insufficiently correlated information, 

 much of it purely empirical, must be subjected to a more 

 definite analysis by physiological and chemical methods. 

 It must be clear, however, even from the superficial review 

 which we have presented that, in its broader conception, 

 the study of infection offers data and material that are far 

 more significant for the investigation of cell reactions than 

 is indicated by their relationship to infectious disease. The 

 phenomena outhned represent deep-seated capacities of 

 cell adjustment which should receive as much attention from 

 the general physiologist as they do from the immunologist. 



REFERENCES 



Bail, O. 191 i. Das Problem der Bakteriellen Infektion. Leipzic, Klinkhardt. 

 BoRDET, J. 1920. Traite de rimmunite. Paris, Alasson. 

 Jordan, E. O. 1920. General Bacteriology. Ed. 8, Pliila., Saunders. 

 Metchnikoff, E. 1901. Immunity dans les Maladies Infectueuses. Paris, 



Masson. 

 Park, W. H., Williams, A. W., and Krumwiede, C. 1924. Pathogenic 



Microorganisms. Ed. 8., Phila., Lea & Febiger. 

 Wells, H. G. 1920. Chemical Pathology. Ed. 4, Phila., Saunders. 



1925. Chemical Aspects of Immunity. N. Y., Chemical Catalogue. 

 Zinsser, H. 1928. Textbook of Bacteriology. Ed. 7, N. Y., Appleton. 



1923. Infection and Resistance. N. Y., Macmillan. 

 Note. For obvious reasons no attempt has been made to give references to 

 any but the larger treatises and summaries which deal with this subject. 



