4126 _EUPHORBIA COROLLATA, 
In one case a dose of three grains proved actively 
cathartic in four hours. In another five grains 
produced vomiting. In a third no effect was 
experienced from twelve grains, exeept thatof a 
moderate laxative. In one instance twenty grains 
_ were given, which produced vomiting three times, 
followed by about twenty alvine evacuations: 
I have placed portions of this plant in the 
hands of several practitioners and medical stu- 
deats, with a request to be informed of the effect, 
when suitable opportunities for its. exhibition had 
occurred. Ina majority of the instances 1 have 
been told, that a cathartic operation had followed 
its use; and sometimes, though less frequently, 
an emetic. It rarely has proved inactive. . 
The Euphorbia corollata must undoubtedly 
be ranked among the more efficient medicines. of 
the evacuating class. Dr. McKeen concludes, 
from his experiments, that it is a very» certain 
purgative, possessing, he thinks, about double 
the strength of jalap. It exerts its cathartic 
efficacy in doses of less than ten grains. If given 
to the amount of fifteen or twenty grains, it is 
very sure to prove emetic; the proportion of its 
failures, being not greater than occurs in the use 
of other emetic medicines. 'The only inconven- 
iences which haye come to my knowledge, as 
