HOW MOLECULES MAKE MASSES 63 



«8 Koll. Zeit. (1929), 50, 39. 

 **Koll. Zeit. (1911), 8, 198, 238. 



40 See "Colloid Chemistry," Vol. Ill, pp. 542-6, Reinhold Pub. Corp., 1931. 



41 "Cold Spring Harbor Symposium" (1940), 8, 216. 



42 Kenneth B. Raper, Third Growth Symposium, 1941, pp. 41-76. 



« "Colloid Chemistry," Vol. V, pp. 1162-73, Reinhold Pub. Corp., 1944. 



44 The phenomenon of specific clumping has been described by W. W. C. Topley, 

 J. Wilson and J. T. Duncan, Brit. J. Exptl. Path. (1935), 16, 116. 



45 Reference should be made to an extensive paper by Professor Leo Loeb (Wash- 

 ington Univ.) in "Colloid Chemistry," Vol. II (1928), pp. 487-514, in which tissue 

 formation is discussed. He concludes that the basic factors leading to the formation 

 of the most primitive tissues and of agglutination thrombi are the same. Both 

 processes find their prototype in the amoebocyte tissue, and gradually undergo 

 various developments and complications in the more complex classes of organisms. 

 "The primary changes underlying these conditions are localized alterations in the 

 colloidal state of certain constituents of the cells, which are probably protein in 

 nature." The differences in colony form shown by the "rough" and the "smooth" 

 dissociants of pneumonococci appear to be consequent upon the nature of their 

 polysaccharide coats or capsules, as shown by Professor Michael Heidelberger 

 (Columbia University), Dr. O. T. Avery (Rockefeller Inst.) and others. 



