MUSCLE GLYCOLYSIS 



85 



TABLE 19 

 Reaction Chain in INIuscle Glycoi-ysis 



(2) Phosphoglucomutase (activated by Mg or Mn) transforms the Cori ester 

 into the Robison ester, Glucose-6-phosphate. 



(3) Phosphohexoseisomerase transforms the Robison ester to the Neuberg 

 ester, Fructose-6-phosphate. 



(4) Adenosinetriphosphate is now necessary as coenzyme to convert the 

 Neuberg ester to Fructose diphosphate (Harden and Young ester) in the presence 

 of phosphohexokinase. In this reaction one r-^ph is utiHsed. 



(5) Aldolase (or zymohexase) now splits the molecule giving a mixture of 

 phosphodihydroxyacetone and 3-phosphoglyceraldehyde. 



(6) Phosphotrioseisomerase can interconvert the two preceding compounds 

 and as the 3-phosphoglyceraldehyde is consumed in the next reaction more is 

 formed from phosphodihydroxyacetone. 



(7) Phosphorylation of 3-phosphoglyceraldehyde occurs in the presence of 

 inorganic phosphate and 1 : 3 diphosphoglyceraldehyde is formed, no enzyme 

 having been found to effect this reaction. 



(8) An oxidation-reduction reaction now occurs and 1 : 3 diphosphoglyceric 

 acid, containing one ^ph is formed. In this reaction triosephosphate dehydro- 

 genase is necessary and also Coenzyme I. The coenzyme is reduced. 



