CONTROL BY REPRESSION 



25 



TABLE 2-1 

 Selected Examples of Repression 



Enzyme " Repressor Reference 



Acetylomithine 5-transaminase ( e ) . . Arginine Albrecht and Vogel ( 1960 ) 



Acetvlornithinase ( e ) Arginine Vogel ( 1953a ) 



Ornithine transcarbamylase ( e ) ... Arginine Gorini and Maas ( 1957 ) 



Acetylomithine permease (e) Arginine Vogel (1960a) 



Arginine-glycine transamidinase (r) Creatine Walker (1959) 



Glutamine synthetase (h) Glutamine DeMars (1958, 1960) 



Imidazoleglycerol phosphate dehy- 



drase ( s ) Histidine Ames and Garry ( 1959 ) 



Imidazoleacetol phosphate transami- 

 nase (s) Histidine Ames and Garry ( 1959) 



L- Histidinol phosphate phosphatase (s) Histidine Ames and Garry (1959) 



L-Threonine deaminase (e) Isoleucine Umbarger and' Brown (1958a) 



Methionine synthetase (e) Methionine Cohn et al. (1953a); Wije- 



sundera and Woods ( 1953, 

 1960) 



Pyrroline-5-carboxylate reductase (n) Proline Yura and Vogel ( 1959 ) 



Tryptophan synthetase (a) Tryptophan Monod and Cohen-Bazire 



(1953b) 



Tryptophan synthetase, Components 



A and B (e) Tryptophan Yanofsky and Crawford (1959) 



Valine transaminase (e) Valine Adelberg and Umbarger (1953) 



Acetolactate-forming enzyme (e, a) Valine Umbarger and Brown (1958b); 



Halpern and Umbarger 

 ( 1959 ) 

 Inosine 5'-phosphate dehydrogenase 



(a) Guanine, Le\in and Magasanik ( 1959) 



8-azaguanine 



Inosinicase (a) Guanine, Levin and Magasanik ( 1959); 



8-azaguanine Magasanik ( 1960) 



Aspartate transcarbamylase (e) ... Uracil Yates and Pardee ( 1957) 



Dihvdroorotase (e) Uracil Yates and Pardee (1957) 



Dihydroorotic acid dehydrogenase (e) Uracil Yates and Pardee (1957) 



Alkaline phosphatase ( e ) Phosphate Horiuchi et al. ( 1959 ) ; 



ToiTiani ( 1960 ) 



/3-Galactosidase (e) Galactose Monod and Cohen-Bazire 



(1953a) 



Histidase (a) Glucose Magasanik et al. ( 1958) 



myo-Inositol dehydrogenase (a) ... Glucose Magasanik et al. (1958) 



Glycerol dehydrogenase (a) Glucose Magasanik et al. (1958) 



Isocitratase (m) Succinate Kornberg et ah ( 1960) 



° The origin of the enzymes is indicated by the letters in parentheses: a, Aerobacter 

 aerogenes; e, Escherichia coli; li, human (HeLa) cells; m. Micrococcus denitrificans; 

 n, Neurospora crassa; r, rat kidney; s. Salmonella typliiimtrium. The enzyme-like 

 acetylomithine permease has been included. 



