144 



AI)Vf:\TrJ!KS IX IJADIOSIOTOPB RESEAllCH 



Nine rabbits were used in these experiments. Quinine Insmuthiodide^^' 

 was used in live cases and bismuth hydroxide in the remaining four. 

 The results obtained were in reasonable agreement. We shall limit the 

 results presented here to those from one of the experiments with quinine 

 bismuth iodide. These results are summarized in Fig. 1. The heights 

 of the vertical columns represent the quantities of bismuth injected 

 daily; the shaded parts of the columns represent the quantities found 



0,5 

 0.4 

 0,3 

 0,2 

 0.1 

 0,0 





8> 



c 



a> 



c 

 ■o 



En 

 o o 

 O o 



mq 



2,65 

 2.50 



2.00 



,50 



.00 



0,50 



Faeces 



0,0 .Urine 



/2 2/2 '/fe "/Z Vz 6^ 7/2 8/2 9/2 lO/j U/a 



Fig. 1 



Di Iribution of bismuth in iho i-aV)bit 



at the corresponding points of injection. The upper black columns 

 represent the quantities found in the daily faeces and the lower black 

 columns the quantities found in the urine. The black rectangles 

 placed in the upper part of the diagram give the contents of the various 

 organs. 



The general results of all the experiments can be summarized as fol- 

 lows : ^1* bismuth is eliminated chiefly in the urine; the quantity of bis- 

 muth found in it is double the amount passed in the faecal matter; 

 it increases during the period of treatment in the urine but this is not 

 so clearly demonstrated in the faecal matter; (2) the heart and lungs 

 contain only a small amount of bismuth; the liver contains quite a small 

 (juantity and the kidneys a fair amount, generally mor(> than d()ul)le 

 lhe amount in the liver; only a very small quantity of bismuth has been 

 lound in 50 cm'^ of l)lo()d. 



