FORMATION OF IMIOSPHATIDES IN LIVER PERFUSION EXPERIMENTS 2G1 



are not influenced, however, by this source of error, since they are not 

 based on determinations of the phosphatide content before and after 

 perfusion but on the ralio of hiliclled and non-labelled phosphatide 

 molecules present in the liver. We may, therefore, conclude from the 

 results described above that lipaemic blood is more effective in the 

 formation of phosphatides in the liver than is normal blood. This result 

 suggests that one of the main reasons for alimentary lecithinaemia is that 

 during the influx of lipaemic blood phosphatide formation in the liver 

 is increased and phosphatides are discharged into the circulation [cf. 

 Aylward et al., 1935]. As the lipaemic blood is changed into normal 

 blood the excess phosphatides are taken up by the liver and other 

 organs, until the "normal" phosphatide content of the blood is reached. 



Suiiiniary 



In oxporimonls in vitro llio amount of labollod phosphatido obtained in shak- 

 ing blood with radioactive sodium phosphate is the same whether normal or 

 lipaemic blood is used. 



In perfusion experiments the lipaemic blood is found to contain more labelled 

 and thus newly formed phosphatide than the normal blood. The same result 

 applies also to the phosphatides extracted from the liver in the perfusion experi- 

 ment. 



References 



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