268 



ADVENTURES IN RADIOISOTOPE RESEARCH 



of the administration of histamin on the permeability of the capillaries 

 by phosphatides is, thus, found. In view of the large fluctuations shown 

 by the values obtained in the experiments in which histamin was ad- 

 ministered, the above result is, however, to be interpreted cautiously. 



Table 5. — Percentage of Labelled Phosphatides Present in the Plasma 

 OF Chicks B3, C3, D3, E^, and F3 after the In.iection of 1 cc. Plasma of Chick 



A3 Containing Labelled Phosphatides 



<>' Conip. also Table :i. 



The permeability of different artificial membranes to phosphatides 

 was investigated by Stjllmann and Verzar (1934). They found that 

 through such membranes which are permeable to water blue and Congo 

 red the plasma phosphatides can penetrate as well. 



UPTAKE OF LABELLED PHOSPHATIDES BY THE ORGANS 



In Ihe preceding chapters, we discussed the rate at which labelled 

 phosphatide molecules located in the plasma penetrate through the 

 capillary wall. We will now describe experiments which were carried 

 out in order to determine to what extent the various organs took up the 

 labelled phosphatides which left the circulation. We arrive at these 

 figures by extracting the phosphatides of the organs and by determin- 

 ing their activity. 



In Table 6, the percentage of labelled phosphatides introduced into the 

 circulation, present at the end of the experiment in several organs, is 

 recorded in the third column. The fourth column of the table contains 

 data on the labelled phosphatide content of the interspaces computed 

 on the assumption that all the labelled phosphatides present are to be 

 found in the extracellular volume. For the extracellular volume of the 

 organs of the rabbit we utilised the figures arrived at by Manery and 

 Hastings (1939). In the fifth column, the distribution of the labelled 



