376 ADVENTURES IX RADIOISOTOPE RESEARCH 



Table 8c. — Effect of Temperature on the ^^P Fractions 



OF the Corpuscles 



Relative specific activity of the P fractions of the corpusclas 



DISCUSSION 



A. Renewal of the acid soluble P compounds in the organs. 



B. Renewal of the acid soluble P compounds in the corpuscles. 



A) Renewal of the acid soluble P compounds present in the organs 



As seen in Table 1, in the course of 4 hours a very appreciable part 

 of the average acid soluble P compounds present ^n many of the organs 

 was renewed. A very active turnover takes place in the mucosa of the 

 small intestine. One half or more of the molecules of the organic acid 

 soluble P compounds present in this organ became renewed in the course 

 of 215 min. This very marked rate of new formation of the organic acid 

 soluble P compounds is of interest in connection with the view put 

 forward by Veezar and others on the role of intermediary phosphoryl- 

 ation processes in the resorption of sugar from the intestine^^^.The highest 

 value for the specific activity of the acid soluble oiganic P was found 

 in the kidneys. The labelled inorganic P diffuses faster into the cells 

 of the kidneys than into those of any other organ. The high value of the 

 specific activity of the acid soluble kidney P is, to some extent, due to 

 the fact that the cellular inorganic P Mithin 215 min acquires a higher 

 value in the kidneys than in other organs. If due regard is taken to this 

 phenomenon we find that, in spite of the fact that the specific activity 

 of the intestinal acid soluble P is lower than that of the corresponding 

 fraction extracted from the kidneys, the rate of renewal in the intestinal 

 mucosa is greater than in the kidneys. 



The rate of renewal of the organic acid soluble P molecules in t he 

 liver and in the lungs (see Table 1) is also quite appreciable. The compa- 

 ratively high value found for the ratio of the specific activities of the 

 organic P and inorganic P in the case of the brain tissue is, at least to 



(i) F. Verzar and E. J. McDougall, Absorption from the Intestine. London 

 (1936). Comp. also E. Lundsgaaud, Z. physiol. Chem. 261, 19 (1939). 



