412 



ADVENTURES IN RADIOISOTOPE RESEARCH 



4,8- 

 4,4- 



4,2 

 4,0 



o 



j: 3,6 



^3,4^ 



^3,2- 

 i 3,0 

 °- 2,6- 



i 2.6 

 o 



" 2,4-1 

 ° 2,2- 

 2,0 

 1.8 



Succinate 



30 



60 



90 120 



Time in minutes 



150 



180 



210 



a40 



Fig. 2. The logarithm of the specific activity of COg excreted is 



plotted against time, following the intraperitoneal injection of iso- 



topic sodium acetate and succinate (Gould et al. (2)). 



b) Skeletal Muscles 



A very different result as stated above is obtained in the study of tiie 

 incorporation of i^C into the total dry tissue of skeletal muscles, a large 

 share of which is due to the fats present. As seen in Fig. 3, the admi- 

 nistration of the dinitro-compound decreases the rate of incorporation 

 of 14C into the muscle tissue both in the initial and in the later phases 

 of the experiment. Our very restricted knowledge as to fatty acid for- 

 mation in the intrusion into the muscles and to that of other labelled 

 compounds makes the interpretation of the above results difficult. II 



-f 



---^ DPP. ______: + 



+ 



I 



50 



— r" 

 45 



60 mm. 



Fig. 3. Effect of dinitro-cyclo-pentylphenol on the incorporation of 

 "C into the total muscle tissue of the mouse, "C injected as 



CHg^COONa. 



