414 



ADVENTURES IN BADIOISOTOi'E RESEARCH 



would be twice as large in the D.P.P. treated animal. If the rate of 

 formation of fatty acids would not be influenced in the muscles of such 

 a mouse, the incorporation of ^^C into fatty acids would be half only 

 in the D.P.P. injected mice of that of controls. Under physiological 



mm. 



Fig. 5. Change of C^* content of brain fractions with time. 



conditions the rate of formation of fatty acids will correspond to their 

 rate of degradation. This is no longer the case in the D.P.P. treated 

 animal which may rapidly loose some of its fat content. 



It is quite possible that fats or their precursors reach the muscles from 

 the liver. Most of the time the i'*C content of the fats in the liver of D.P.P. 

 treated mice is lower than the ^*C content of the fats of controls. This 

 may also explain the low ^*C values in the muscle fats of the dinitro- 

 cyclo-pentylphenol treated mice. Further information on this point 

 could be obtained by studying the intrusion into the muscles of labelled 

 fatty acids, labelled aceto-acetonate or other labelled precursors intro- 

 duced into the circulation. 



