INCOKPOKATIOX OF LAB. ACETATE CAllBOM ("C) INTO TISSIK FRACTIONS 4] 5 



c) Brain 



The results plotted in Fig. 4(a) and 4(&) indicate a slight effect only 

 of injection of D. P. P. on the metabolic steps of the brain in which acetate 

 carbon participates. The total labelled acetic acid conient of the ra1 



Skin 



Total tissue 



60 mm. 



Heart 

 Total tissue 



60 min. 



Fig. 6. Effect of dinitro-cyolo-pentylphenol on the im^orporation 

 of i*C into total tissue of skin (a) and heart (b) of the mouse, ^*C 



injected as CHgi^COONa. 



was found by Gould et al. (2) to decline during the same time- 

 interval to 1/3 of its initial value as well. We can expect a very rapid 

 metabolic rate in the brain in view of the high oxygen consumption of 

 that organ. The striking decline in the activity of the fat free brain 

 with time is seen in Fig. 5. After 30 min only, the activity of the acid, 

 soluble and protein fractions is less than half of the value observed after 

 10 min. The slight increase in the ^^C content demonstrated by the last 



