BATE OF PENETRATION OF IONS INTO ERYTHROCYTES 



497 



PENETRATION OF PHOSPHATE INTO NUCLEATED CORPUSCLES 



Tlie rate ul' inteieluuige between plasma phosphale and corpuscle 

 phosphate was found to be much slower in hen's blood Ihan in blood 

 containing non-nucleated erythrocytes. The rate of renewal of the organic 

 P compounds was also found to be slower in the corpuscles of the hen. 

 The distribution of ^-P between plasma and corpuscles of the hen is 

 seen in Table 2. 



T.\BLE 3. — EXTKNT OF RENEWAL OF Aci U SOLIBLE P CoM- 

 POI'NDS IN THE CORPUSCLES OF THE HeN IN THE CoiTRSK 



OF 4.7 Hours at 37° 



The P atoms present in the nucleated erythrocytes of the frog were- 

 found to be replaced at a yery slow rate, as seen in Table 4. 



Table 4. — Distribution of ^^P between Plasm.a. 



AND CORPI'SCLES OF THE FrOG IN EXPERIMENTS 

 IN VIVO 



RATE OF PENETRATION OF 32p intO THE CORPUSCLES IN THE 

 PRESENCE OF EXCESS PLASMA PHOSPHATE 



In two experiments, we added besides ^sp an appreciable amount of 

 additional sodium phosphate to the blood increasing the inorganic 

 phosphate content of the plasma to several times its normal value. 

 As seen in Table 5, the rate of penetration of ^ap into the corpuscles is 

 not much influenced by a very substantial increase in the phosphate 

 concentration of the plasma. Tliis result is to be interpreted in Ihe follow- 



32 Hevesy 



