500 



ADVENTURES IN RADIOISOTOPE RESEARCH 



is present in the adhering plasma. While, usually, this ^ap can be disre- 

 garded, that is not the case in experiments of short duration carried 

 out at low temperatures. It is, therefore, of importance to remove the 

 adhering plasma in such experiments. In the experiment lasting 7 hours, 

 we omitted washing of the corpuscles. The same amount of ^ap which 

 penetrated into the corpuscles in the course of 7 hours at 0° was found 

 to be present at 37° after about I hour. By increasing the temperature 

 from 0° to 37° the rate of penetration of phosphate into the corpuscles 

 thus increases about 14 times. 



Table 6. — Effect of Temperatitre on the Rate 



OF Penetration of ^^p into the Corpuscles of 



THE Rabbit 



A marked effect of increasing temperature on the rate of penetration 

 of phosphate can be expected in view of the fairly slow rate of penetra- 

 tion of phosphate into the corpuscles. Usually a low rate of diffusion or 

 of a similar process goes hand in hand with the high temperature coeffi- 

 cient. The diffusion rate equals 



D = A.S.e 



BT 



In this equation, A denotes the number of collisions, S the probability 

 of energetically satisfactory encounters, Q the energy of activation, 

 R the gas constant, and T the absolute temperature. 



Since S is often = 1, the magnitude of e-lvv determines mainly the 



Q 

 rate of diffusion. In the case of a slow penetration, e" r? will be small 



and Q correspondingly large. The effect of a change of T on the value 



