160 NUCLEOPROTEINS, NUCLEIC ACIDS, RELATED SUBSTANCES 



REVIEW QUESTIONS ON NUCLEOPROTEINS 



1. Which types of protein have been found in nucleoproteins? How much is 

 protein and how much is nucleic acid in a few typical nucleoproteins? 



2. Name eight compounds that may be obtained from nucleic acids on hydrolysis? 

 To what class of compoimds does each belong? Name some other examples of each 

 class. 



3. Define nucleoside and nucleotide, givirig an example of each. Which nucleo- 

 tides are associated with (1) vitamins, (2) enzymes? 



4. Compare the probable structure of the dinucleotide, adenylic acid — cytidylic 

 acid with the pyridine and flavin dinucleotides. Point out similarities and differ- 

 ences. 



5. Catalog the linkages that join together the parts of a nucleic acid. 



REFERENCES AND SUGGESTED READINGS 



Chargaff, E., Lipshitz, R., Green, C, and Hodes, M. F., "The Composition of Des- 

 oxyribonucleic Acid of Salmon Sperm," J. Biol. Chcm., 192, 223 (1951). 



Cold Spring Harbor Symposia on Quantitative Biology, Nucleic Acids and Nucleo- 

 proteins, Vol. XII, The Biological Laboratory, Cold Spring Harbor, N. Y., 1947. 



Davidson, J. N., The Biochemistry of the Nucleic Acids, John Wiley and Sons, Inc., 

 New York, 1950. 



Green, H. N. and Stoner, H. B., Biological Actions of the Adenine Nucleotides, 

 H. K. Lewis and Co., Ltd., 1950. 



Mirsky, A. E. and Ris, H., "Isolated Chromosomes," J. Gen. Physiol, 31, 1 (1948). 



Schlenk, F., "Chemistry and Enzymology of Nucleic Acids," Advances in Enzymol- 

 ogy, 9, 455 (1949). 



Stanley, W. M., "Purification of Tomato Bushy Stunt Virus by Differential Centrifu- 

 gation," J. Biol. Chem., 135, 437 (1940). 



Symposia of the Society for Experimental Biology, No. 1, Nucleic Acid, The Uni- 

 versity Press, Cambridge, England, 1951. 



Symposium on Biochemistry of Nucleic Acids, J. Cellular Comp. Physiol., 38, 

 Supplement, 1951. 



Tamm, C, Hodes, M. E., and Chargaff, E., "The Formation of Apurinic Acid from 

 the Desoxyribonucleic Acid of Calf Thymus," J. Biol. Chem., 195, 49 (1952). 



