38 



MUTATIONS 



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STAGE 



Figure 10. Isotope dilution curves with anti-B for 

 male parent, A2B (curve 1); female parent AiB 

 (curve 2); 11 month male infant, AoB (curve 3). 



individuals would generally have low frequencies of mutant cells. We 

 have a few experiments on parents and children of known genotypes. 



In this experiment (Fig. 10), which is with anti-B, the parents are 

 both AB. One is an AiB, and one is an AoB. The infant, 11 months old, 

 is an AoB. You can see that the non-B proportions are identical. The 

 B allele of the infant is one of the parental B alleles, and the age 

 differential is large. This was done through the Chicago Blood Donors 

 Association. They were very cooperative in trying to find families with 

 AB parents. 



Cotterman: How was the blood-type determination made on the 

 child? With Dolichos anti-Ai? 



