244 



INDEX 



Benzpyrene, 196 



Beta-propiolactone, 110, 173, 187, 

 233 



Blood groups, ABO, 16-46 



Bombay factor, 20, 22 



Bone marrow, number of stem cells 

 in, 41 



Brain, consei'vation of DNA in, 184- 

 85 



Bromodeoxycytidine, 149 



Bromouracil, 65, 88, 92-93, 149, 151- 

 52 

 as a deoxynucleotide triphos- 

 phate, 94 

 incorporation into DNA, 89 

 mutagenic action of, 92 



C-mitotic poisons, 231 

 Caffeine, 89-90, 98, 176, 179, 188-89, 

 194, 200-201, 203, 219 



absorption of, 204-6, 211 



access of, to the gonads, 211-12, 

 216 



and spontaneous mutation rate in 

 man, 226 



concentration of, in the human 

 fetus, 216 



consumption of, 208-9 



cumulation and persistence of, in 

 the body, 206 



DNA replication and, 228 



effect of, on bacteria, 220 



effect of, in Drosophila, 221-22, 

 225 



exposure to, 203 



induced mutation rate, 217 



metabolism of, 207 



metabolism of, in bacteria, 213 



mutagenic activity of the metab- 

 olites of, 208 



mutagenic effects of, in bacteria, 

 214 



mutagenic effects of, in Drosoph- 

 ila, 214 



mutagenicity of, in mice, 222-23 



penetration of, to sites of action, 

 211 



psychic stimulation of, 210 



radiation equivalence for, 218, 

 220-21 



reaction to, 210-11, 213 



sensitivities to, 209 



testing the effect of, 227 



Caffeine mutagenesis, 214 

 linear function of dose, 216 



Carbon monoxide, 198 



Carcinogens, 196 



Catalase, 123-25 



Catechols, 172 



Cell, reactive sites on, 34 



Chemical mutagens, a standard test 

 for, 234 



Chlamydomonas, amino acid require- 

 ments in eugametos, 3"> 

 amino acid requirements in Rein- 

 hardi, 69 



Chloral hydrate, 169, 172, 231 



Chloramphenicol, 217 



effect on protein and nucleic acid 

 synthesis, 60 



Chlorine, 196 



Chlorogenic acid, 201 



Chlorouracil, 92 



Chondrodystrophy (Achondroplasia), 

 14-15 



Christmas disease, 71 



Chromosomal aberrations, depend- 

 ence on the age, 231 



Chromosome aberrations, 35, 65, 174- 

 75, 187-88 



Co-agglutination, 26, 34 



Coal-tar dyes, 197 



Coffee-drinking, patterns of, 209 

 reactions of twins to, 210 



Colchicine, 230 



Cross-linkage, 79 



CysC-mutants, deletions among, 118- 

 19 



Cytosine, 89, 155 



deamination in viral RNA, 59 



DDT, 197 



Deamination, of adenine, 82 



"Deletions," 104, 118 



Delphmiimi ajacis, unstable genes 

 in, 51 



Deoxyguanosine, 113 



Deoxynucleotide triphosphate, 94 



Deoxyribonuclease, 81 



Diaminopurine (2, 6-Diamino), 97, 

 149, 151 



Dictyate stage, 183 



Diepoxides, 187 



Diepoxybutane, 80, 105, 109, 131-34 

 lethals and translocations in Dro- 

 sophila, 110 



