INDEX 



245 



Diethyl sulfate, 100, 102-3, 113 

 alkylation of guanine by, 177 

 Digitoxigenin, 169 

 Dimethyl sulfate, 101, 113 

 DNA, conservation of, in brain, 184- 

 85 

 conservation of, in liver, 184-85 

 incorporation into aminopurine, 



89 

 incorporation into bromouracil, 



89 

 inosine in, 98 



replication and caffeine, 228 

 DNA polymerase, 90, 144 

 Doubling dose, in man, 223 

 in mice, 223-24 

 meaningfulness of, 223-24 

 Drosophila, diepoxybutane, lethals 

 and translocations in, 110 

 effects of caffeine in, 221-22, 225 

 heterochromatic segments in, 122 

 mutagen specificity in, 128 

 mutagenic effects of caffeine in, 



214 

 mutagenicity of heavy water in, 



98 

 somatic crossing over in, 56 

 Drosophila fnnehris, mutants, visi- 

 ble in, 69 

 Drosophila virilis, unstable genes in, 



51-52 

 Drug resistance, in bacteria, 190 

 Drugs, genetic hazards of, 168 



EDTA, 116 

 Enovid, 199 

 Epinephrine, 169, 172 

 Escherichia coU, amino acid starva- 

 tion in auxotrophs, 62 

 galactose region of, 4 

 lysine reversions, 135 

 manganese chloride, mutagenic 



effect in, 115-17 

 mutator strain of, 68 

 phosphatase system in, 159 

 reversions at the histidine locus 



in, 134 

 single and double mutations in, 



53, 55 

 tryptophan reversions in, 133 

 tryptophanless strain, 131 

 UV induced mutations in, 132 

 Escherichia coll B, T4-resistance in, 

 202 



Estradiol, 200 



Ethoxycaffeine, 98 



Ethyl alcohol, 195 



Ethylated guanine 108-9, 113 



Ethylene imine, 67, 79-81, 110 



Ethylene oxide, 80, 109, 173 



lethals and translocations in Dro- 

 sophila, 110 

 Ethylethane sulfonate, 100, 102, 105- 

 8, 111-12, 131 



action on phage. 111 

 Ethyl guanine, 101 

 Ethylmethane sulfonate, 100, 103, 



107, 149, 151 

 Ethyl sulfate, 67 



Ferrous chloride, 116 

 Ferrous sulfate, 116 

 Fertility, relative, 5 

 Fluoride, 197 

 Formaldehyde, 80, 114, 134, 172 



action of adenosine riboside, 114 

 Furfuryl alcohol, 201 



Garlic extracts, 197 

 Genes, penetrance of, 34 



unstable, 3 

 "Gene conversions," 135 

 Ghosts, red cell, 23 

 Gland, shell-forming, 46-47 

 Glucosylation, phage T4, within the 



rll region, 143 

 Glyceraldehyde, 202 

 Gonads, access of caffeine to, 211-12, 



216 

 Grigg effect, 135 

 Guanine, 89, 93, 103, 155 



alkylation of, 105 



alkylation of, by diethyl sulfate, 

 177 



Heat, induction of mutation in bac- 

 teria with, 86-87, 149 



Heavy water, mutagenicity of, in 

 bacteria, 98-99 

 mutagenicity of, in Drosophila, 

 98 



Heliotrin, 79 



Hemophilia, 6 



Hepatitis virus, 174 



Heterochromatic segments, in Dro- 

 sophila, 122 



