246 



INDEX 



Histidine, 54 



locus, reversions at, in E. coli, 

 134 

 Histidine markers. Bacillus subtilis 



in, 55 

 Histidine system, mutations in, 3 

 "Hit poison," 99 

 Hodgkin's disease, alkylating agents 



in, 170-71 

 "Hot spot," 136, 156, 160 



in bacteria, 144 



and specific mutagens, 150 



spontaneous, deletion, 148 

 Hydrocortisone, 169 

 Hydrogen peroxide, 114, 116, 124-25 

 Hydroxylamine, 83, 143, 149 

 Hydroxylmethyl cytosine, 96, 142-43 



deamination of, 82 

 Hypoxanthine, 97, 201 



Indouracil, 92 



Induced mutation, probability of per 



cell, 222 

 Induced mutation rates, in different 



gametogenic stages, 127 

 Inosine, in DNA, 98 

 Inositol, requiring strain of Neuro- 



spora, 131, 134 

 Inositol reversions, 133 

 Insecticides, 197 

 Intragenic suppressors, 160 

 Iron salts, 198 

 Isopropyl methane sulfonate, 67 



Jellies, contraceptive, 199 



Klinefelter's syndrome, 232 



maternal age dependence of, 232 



Leaf tissue, growth patterns of, 51 

 Lectin, bi-specific or heteroligating, 



32 

 "Lethal hit," 112 



Lethal mutations, in Neurospora, 60 

 Lethals, sex-linked recessive in man, 



227 

 Leucine, mutants, 4 

 Leucine reversion, 133 

 Leukemia, 34 

 Liver, conservation of DNA in, 184- 



85 

 Lysine, locus, reversions at, in E. 



coli, 135 



Maize, sectorials in, 51 



variegation in, 49 

 Manganese chloride, 115 



mutagenic effect in E. coli, 115-17 



mutagenic effect in penicillin, 117 

 Manganese salts, 198 

 Manganous acetate, 116 

 Manganous sulphate, 116 

 Methemoglobinemia, 173 

 Methenamine, 169, 171 

 Methionine, 130-31 



cistron in yeast, 53 

 Methylated guanine, 113 

 Methyl guanine, 108 

 Methylmethane sulfonate, 112 

 Methyl uric acid, 207 

 Methyl xanthine, 207 

 Mice, doubling dose in, 223-24 



mutagenicity of caffeine in, 222- 

 23 



reduction division in, 230 



sex-linked lethals, 191 



tests of mutagens in, 224 



XO, induced by irradiation, 230 

 Microorganisms, mutagen specificity 

 in, 129 



mutation rates in, 55 



peroxidase in, 123 

 Mitosis, phytohemagglutinin-induced, 



186 

 Mongolism, 15, 65, 230 



maternal age dependence of, 231 

 Morphine, 79, 169, 172, 186 

 "Mosaics," 39, 40-42, 86 

 Mosaics, Ao + 0, 36 

 Mussels (Mytilus edulis) , 46 



blue pigment, 46 



cell lineage in, 48 



free-swimming larval stage, 47 



mutation rate in, 46-51 

 Mustard gas, 79 

 Mustard seed, 197 

 Mutagenic action, of bromouracil, 92 

 Mutagenic activity, 175 



meaningful tests for, 168 



metabolites of caffeine of, 208 

 Mutagens, reactive to pretreatment, 

 116 



tests of, in mice, 224 



also see specific chemical 

 Mutagen specificity, 126, 132, 135- 

 36 



in Drosophila, 128 



in microorganisms, 129 



