INDEX 



247 



Mutants, aminopurine induced, 104 

 double, in Bacillus subtilis, 54 

 induced, by base analogues, 102 

 mechanisms for induction of, 120 

 visible, in Drosophila fu7iebris, 

 69 

 Mutational events, independence of, 



53 

 "Mutation index," 141, 203 

 Mutation of two alleles, in An- 

 tirrhinum, 57 

 Mutation rates, ABO system and, 

 17-46 

 age dependence, 45 

 caffeine, and spontaneous rate in 



man, 226 

 dependence on division rate, 46 

 in mussels, 46-51 

 in strains LT2 and LT7 of Sal- 

 monella, 58 

 in yeast, in meiosis, 17 

 mistakes in, 4 

 sex dependence of, 16 

 Mutation rates in microorganisms, 



55 

 "Mutation rate per generation," 58 

 Mutations, age dependence of, in 

 man, 16 

 alkylating agents, 79 

 back, 2 



5-bromouracil induced, 90 

 by a mistake in incorporation, 89, 



94 

 caffeine-induced, 60 

 definition of, 1, 72 

 expression in man and in bac- 

 teria, 70 

 forward, 2 

 forward in yeast, 67 

 individual units of, 152, 156 

 induced, in phage, 83-85 

 induced by 2-aminopurine, 117 

 lethal, 70 



operational terms for, 64 

 specificity in forward, 66 

 spontaneous, 136 

 "spontaneous" in man, 176 

 spontaneous, in Neurospora, 88 

 UV induced in E. coli, 132 



Neighbor interaction, 154-55 

 Neurofibromatosis, 14 



Neurospora, adenine plus inositol re- 

 quiring strain of, 131, 134 

 lethal mutations in, 60 

 mutations, spontaneous in, 88 

 Nicotine, 169, 174, 195-96 

 Nitrate, 116 

 Nitrites, 80, 173 

 Nitrogen mustard, 169 

 Nitrous acid, 82-83, 88, 110, 149-51, 

 172, 179 

 deamination of nucleic bases by, 



177 

 induction of mutation in bacteria 



by, 86 

 treatment of bacteria with, 85 

 Norethynodrel, 199-200 

 Nucleoside triphosphate, 104 



Organic peroxides, 113, 124 



Paraldehyde, 169, 172 

 Penetrance, 42 



of gene, 34 

 Penicillium, mutagenic effect of man- 

 ganese chloride in, 117 

 Pentobarbital, 202 

 Pericarp, growth patterns of, 51 

 Peroxidase, in microorganisms, 123 

 Peroxides, amino acid, 114 

 Peyotl, 176 

 pH, 146 



Phage, action of ethylethane sulfc 

 nate on 111 



induced mutations in, 149-53 



in vitro, in vivo, 149 



mutations, induced in, 83-85 



Tessman's, 82 

 Phage T4, 82-83, 136 



deletions in, 146-49 



glucosylation, within the rll re- 

 gion, 143 



incorporation of 2-aminopurine 

 in, 91 



quiet regions in, 139 



revei'tants in, 144-46 



spontaneous mutations, 138 

 Phaseolus, 33 

 Phenols, 172, 201 

 Phenoxybenzamine, 169, 171 

 Phenyl mercuric compounds, 199 

 Polycythemia, 35 

 Proflavine, 149 

 Progesterone, 199-200 

 Proline, 121 



