SUBSTRATE 



Sensitizing ^ 

 Fat solvent ^ 



O 



Protein-enzyme 

 complex 





v-^w.wCV 



• .V *: ' 









.» 



■J. 



•V • 



FIG. 4B. Mechanism of Sensitizing Action of Fat Solvents on Insect Cuticle. 

 The uptake of a fat solvent, such as chloroform, results in a swelling of the 

 bound-lipid mosaic network. There is a simultaneous displacement of labile lipid, 

 resulting in an increase in cuticle permeability to fat-soluble and water-soluble 

 substances. 



29 



