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Applied Biophysics 



Figure 3 shows the reaction chart of a favorably-responding 

 tumor which was an epithelioma with keratinized foci, 

 Broders grade 2.* The maHgnant tissue reacts rapidly to 

 treatment, with a marked increase in number of dififerentiating 



80 



40 - 



FIG. 3. Reaction Chakt of Epithelioma 



cells which subsequently disintegrate. The mitotic and resting 

 cells decrease in number and disappear. Clinically, healing of 

 the lesion was noted after 3 months and the patient has remained 

 well and symptom-free for 5 years. 



Figure 4 represents the reaction to treatment of another epi- 

 thelioma of the cervix uteri, clinical stage 2, Broders grade 3. 

 The effect of 3 radium insertions in this case is approximately 

 equal to that of a single insertion in the case of figure 3, i.e., 

 there is some reduction in the percentage of viable cells and a 

 corresponding increase in the percentage of nonviable cells. This 

 change does not, however, lead to the complete disappearance 

 of viable cells, and the tumor tissue is thus able to recover from 



* Broders's histological grading of malignancy is based on the degree and extent 

 of cell dedifferentiation. The least malignant, i.e., the most differentiated form, con- 

 stitutes grade 1 and consists of 0% to 25% of dedifferentiated cells. Grade 2 contains 

 25% to 50%; grade 3, S07o to 75%; and grade 4, 75% to 100% of dedifferentiated 

 cells. 



