PHARMACOLOGY 



containing compounds, particularly glutathione. In fact, extensive 

 studies by Voegtlin, Eagle, and their associates, indicate that the 

 therapeutic effect of the arsenicals in protozoan infections is dependent 

 on a reaction with cytoplasmic sulfhydryl groups. 



As understanding of the biochemical mechanisms of energy 

 transfer and of its catalysis is advanced, the fundamental actions and 

 metabolic alterations of more and more of the known drugs and poisons 

 will be elucidated, and unprecedented opportunities will be afforded 

 for the rational development of new therapeutic agents. 



References 



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(4) Bueding, E., unpublished research. 



(5) Cattell, M., and Gold, H., J. Pharmacol. Exptl. Ther., 62, 116 (1938); 

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(6) Clark, A. J., in Heffter's Handbuch der experimentellen Pharmakologie. 

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(12) Haas, E., J. Biol. Chem., 155, 321 (1944). 



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(14) Hirsch, J., Science, 96, 139 (1942). 



(15) Klein, J. R., and Harris, J. S., J. Biol. Chem., 124, 613 (1938). 



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(18) McCawley, E. L., Federation Proc, 4, 129 (1945). 



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