C. L. HOAGLAND 



of this complex disorder would mean to the future development of 

 medical biochemistry, however, few diseases offer more exciting 

 potentialities. It will be recalled that earlier, in a consideration of 

 those tissues which have been of greatest use in a study of the chemical 

 and physical laws of living matter, scarcely a moment's reflection was 

 needed to place muscle first. Indeed, it was indicated that the physio- 

 logical basis of activity of any organ or organ structure as we regard 

 it today is but largely an extension of concepts first derived for muscle. 

 Is it too much to hope, therefore, that eventually the solution of the 

 clinical syndrome which we recognize as progressive muscular dys- 

 trophy may provide many of the new and fundamental concepts we 

 shall require in order ultimately to achieve the description of disease 

 in terms of the nature of altered physiological and chemical mecha- 

 nisms at work in the cells and tissues of the affected organism? 



References 



(1 



(2 

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(5 



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 (8 



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