KESOBPTIOX EATE OF INJECTED NaH'^CO, 837 



mediated through hormonal action. ACTH increased the "CO^ exhalation per se 

 and an ACTH treatment bcfoic irradiation annihilated the effect of the latter. 

 It is not out of the question, therefore, that the X-ray effect is duo to a Vjlocking of 

 ACTH formation. Adrenaline decreased the output of ^^COg similarly to irradiation, 

 but irradiation was not found to release adrenaUne in the body. A combined treat- 

 ment, giving adrenaline before irradiation, caused a higher output of ^^C02 than 

 from control mice. These facts arc not compatible with the hypothesis that the 

 X-ray effect is mediated through adrenaline action. 



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