EFFECT OF ADRENALINE ON PLASMA AND TISSUE CONSTINTENTS 



613 



It may be due to a decreased circulation rate in the bone tissue that, 

 under the action of adrenaline, incorporation of ^'-P into the skeleton is 

 reduced. Furthermore, recrystallization of the bone apatite, which to a 

 large extent is responsible for the ^^P incorporation, is presumably an 

 enzymatic process and it is quite possible that adrenaline interferes with 

 the latter. 



The markedly lower ^sp content of the plasma of adrenaline injected 

 mice could be due to a lower resorption rate due to the effect of adrenaline 

 or an increased rate of efflux from the circulation. It is hardly probable 

 that the former is the case. Adrenaline was found (1954) to decrease 

 the resorption rate of intraperitoneally injected bicarbonate, the differ- 

 ence in the rate of resorption due to the presence of adrenaline manifests 

 itself, however, in the course of the first few^ minutes only. We can expect 

 phosphate to show a similar behaviour. To make sure that we are con- 

 fronted with an enhanced rate of loss of ^^p by the plasma under the 

 effect of adrenaline, we injected labelled phosphate intravenously into 

 rabbits, eliminating thus the possible role of a resorption process. 



The decrease observed in the ^^P content of the plasma of the adrenaline 

 injected mouse is due to an increased rate of interchange between plasma 

 and extra vascular phosphate, and not to an increased exodus of plasma 

 phosphate. This follows from the fact that, in our experiments with 

 mice taking 15 min, the inorganic P content of the plasma is not influ- 

 enced by the presence of adrenaline, as seen in Table 2. 



PiNCUS and assoc. (1933) investigated the effect of subcutaneously 

 administered 80 microgram/kgm of adrenaline on the inorganic phosphate 



Table 2. — Inorganic P Content of the Plasma 

 or Controls and of Adrenaline Injected Mice 



